Table 3.

A summary of therapeutic drugs that are used in the control of infectious diseases, and information about CYP450 enzymes that are known to affect their metabolism

Disease	Therapeutic drug	CYP450 enzymes that affect drug metabolism
Malaria	Artemether	CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5,
	Lumefantrine	CYP2D6, CYP3A4, CYP3A5
	Amodiaquine	CYP1A1, CYP1B1, CYP2C8
	Mefloquine	CYP3A4, CYP3A5
	Chloroquine	CYP2C8, CYP2D6, CYP3A4, CYP3A5
	Sulfadoxine-pyrimethamine	CYP2C9, CYP2D6
	Primaquine	CYP1A1, CYP1A2, CYP3A4, CYP3A5,
	Quinine	CYP1A1, CYP1A2, CYP3A5
HIV	Efavirenz	CYP2B6, CYP3A4, CYP3A5
	Saquinavir	CYP3A4, CYP3A5
	Abacavir	No CYP450 enzyme
	Maraviroc	CYP3A4, CYP3A5
	Nevirapine	CYP2B6
	Indinavir	CYP3A4, CYP3A5
	Nelfinavir	CYP3A4, CYP3A5
	Ritonavir	CYP3A4, CYP3A5
	Lopinavir	CYP3A4, CYP3A5
Tuberculosis	Isoniazid	CYP1A2,CYP2C19,CYP2E1
	Rifampin (Rifadin, Rimactane)	CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP3A4, CYP3A5
	Ethambutol (Myambutol)	CYP2C9, CYP2C19, CYP2E1
	Pyrazinamide	CYP1A2, CYP3A4
Leishmaniasis	Pentostam	No CYP450 enzyme
	Glucantime	No information
	Pentamidine	CYP1A1, CYP1A2, CYP2C8, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP4A11
	Amphotericin B	No CYP450 enzyme
	Ketoconazole (on trial)	CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP3A7
Human African Trypanosomiasis	Pentamidine (for Trypanosoma brucei gambiense)	CYP1A1, CYP1A2, CYP2C8, CYP2C19, CYP2B6, CYP3A4, CYP3A5, CYP4A11,
	Suramin	No CYP450 enzyme
	Melarsoprol	No information
	Eflornithine	No information
	Nifurtimox	No information
South American Trypanosomiasis (Chagas disease)	Benzimidazole	No CYP450 enzyme
	Nifurtimox	No information
Leprosy	Rifampin	CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP3A4, CYP3A5
	Dapsone	CYP2C8, CYP3A4, CYP3A5
	Clofazimine	CYP3A4, CYP3A5
Lymphatic filariasis	Diethylcarbamazine (DEC)	No CYP450 enzyme

Information has been compiled from the literature and from online databases.