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. Author manuscript; available in PMC: 2013 Dec 19.
Published in final edited form as: Dev Biol. 2010 Dec 23;351(1):10.1016/j.ydbio.2010.12.025. doi: 10.1016/j.ydbio.2010.12.025

Fig. 3. Loss of E2F1-3 causes degradation and opacification of the lens.

Fig. 3

(A) Hematoxylin and eosin staining of lenses from of E2f1-/-;E2f2-/-;E2f3LoxP/LoxP (control) and cry-cre;E2f1-/-;E2f2-/-;E2f3LoxP/LoxP (cry-cre) embryos (E16.5) and neonates (P1, P7 and P16). (B) High magnification of P1 control and cry-cre lenses. Note the prominent vacuolation in the cortex of the TKO fiber compartment. (C) control and cry-cre mice and (D) dissected lenses from control and cry-cre mice at 3 weeks old. Normal adult lenses are spherical and transparent, whereas TKO lenses are distinguished by decreased size, irregular surface and opacity (cataract).