Table III.
The top 20 upregulated and downregulated miRNAs.
| miRNA name | NCa | MNb | Fold change (log2)c | P-value |
|---|---|---|---|---|
| Downregulated miRNAs | ||||
| hsa-miR-217 | 191.8607 | 0.01 | −14.22777294 | 0 |
| hsa-miR-216a | 66.6825 | 0.01 | −12.70309232 | 5.5967E-245 |
| hsa-miR-216b | 38.1222 | 0.01 | −11.89641592 | 2.4708E-140 |
| hsa-miR-95 | 29.9978 | 0.01 | −11.5506409 | 1.4472E-110 |
| hsa-miR-671-5p | 22.1858 | 0.01 | −11.11542074 | 6.07198E-82 |
| hsa-miR-3653 | 20.311 | 0.01 | −10.98804541 | 4.49572E-75 |
| hsa-miR-1285-3p | 14.8739 | 0.01 | −10.53856732 | 3.75197E-55 |
| hsa-miR-200c-3p | 1181.5995 | 1.1702 | −9.97977026 | 0 |
| hsa-miR-29a-5p | 9.9993 | 0.01 | −9.9656833 | 2.72194E-37 |
| hsa-miR-627 | 9.7493 | 0.01 | −9.92915478 | 2.24289E-36 |
| hsa-miR-425-3p | 9.4368 | 0.01 | −9.88215398 | 3.13127E-35 |
| hsa-miR-503 | 8.7493 | 0.01 | −9.77302376 | 1.03401E-32 |
| hsa-miR-193a-5p | 8.3744 | 0.01 | −9.70984202 | 2.44579E-31 |
| hsa-miR-382-5p | 7.6869 | 0.01 | −9.58625814 | 8.07652E-29 |
| hsa-miR-135b-5p | 7.1245 | 0.01 | −9.47664493 | 9.29106E-27 |
| hsa-miR-4802-3p | 6.812 | 0.01 | −9.41193458 | 1.29711E-25 |
| hsa-miR-1246 | 6.812 | 0.01 | −9.41193458 | 1.29711E-25 |
| hsa-miR-500a-5p | 6.6245 | 0.01 | −9.37166775 | 6.30846E-25 |
| hsa-miR-500b | 6.562 | 0.01 | −9.35799181 | 1.06882E-24 |
| hsa-miR-5588-5p | 5.6246 | 0.01 | −9.1356067 | 2.90831E-21 |
| Upregulated miRNAs | ||||
| hsa-miR-486-5p | 26.5605 | 13344.793 | 8.97277891 | 0 |
| hsa-miR-208b | 0.01 | 4.8609 | 8.92507964 | 9.79541E-22 |
| hsa-miR-133a | 0.6874 | 306.0547 | 8.79842396 | 0 |
| hsa-miR-449a | 0.01 | 4.1407 | 8.69373087 | 1.23214E-18 |
| hsa-miR-195-3p | 0.01 | 2.2504 | 7.81403765 | 1.68736E-10 |
| hsa-miR-449c-5p | 0.01 | 1.9804 | 7.62964804 | 2.45229E-09 |
| hsa-miR-133b | 0.0625 | 9.9918 | 7.3207446 | 5.40583E-42 |
| hsa-miR-204-5p | 92.2431 | 2212.9552 | 4.58438944 | 0 |
| hsa-miR-410 | 0.25 | 5.3109 | 4.40895636 | 9.13765E-19 |
| hsa-miR-21-3p | 4.1872 | 78.134 | 4.22189274 | 5.5898E-249 |
| hsa-miR-10b-5p | 55198.7661 | 628948.7014 | 3.51023443 | 0 |
| hsa-miR-19a-3p | 5.1871 | 51.3092 | 3.30621744 | 6.9257E-134 |
| hsa-miR-4661-5p | 0.125 | 1.1702 | 3.22675512 | 0.000345083 |
| hsa-miR-199b-5p | 1.5624 | 13.8625 | 3.1493517 | 1.00921E-35 |
| hsa-let-7i-5p | 248.6065 | 2045.6153 | 3.04059893 | 0 |
| hsa-miR-144-3p | 0.9999 | 8.1915 | 3.03427193 | 5.66076E-21 |
| hsa-miR-486-3p | 0.5 | 3.7807 | 2.91865338 | 4.6769E-10 |
| hsa-miR-19b-3p | 24.4357 | 181.8325 | 2.89554775 | 0 |
| hsa-miR-941 | 1.9374 | 12.7823 | 2.7219537 | 1.49032E-28 |
| hsa-miR-1468 | 1.4999 | 9.0916 | 2.59966789 | 9.12913E-20 |
The top upregulated and downregulated microRNAs (miRNAs) were based on the fold change value (log2). The fold change was the largest in the 40 upregulated miRNAs. The absolute value of the fold change (log2) was the largest in the 286 downregulated miRNAs.
a
Standard expression values in NC samples;
b
Standard expression values in MN samples
c
Fold change formula: fold change = log2 (MN standard expression/NC standard expression).
MN, membranous nephropathy; NC, normal controls.