Table V.
miRNA base edit comparison between the MN and NC groups (Top 10 ratio >1, 6 ratio = 1, top 6 ratio <1).
| miRNA name | Count with base edit/total edit (MN)a | Count with base edit/total edit (NC)b | Ratio (MN)/ratio (NC)c |
|---|---|---|---|
| Ratio (MN)/ratio (NC) >1 | |||
| hsa-miR-1 | 25.59 | 0.48 | 53.20 |
| hsa-miR-542-3p | 16.55 | 0.40 | 41.80 |
| hsa-miR-190a | 9.09 | 0.28 | 32.80 |
| hsa-miR-30b-5p | 19.68 | 0.75 | 26.17 |
| hsa-miR-146a-5p | 22.82 | 1.26 | 18.13 |
| hsa-miR-146b-5p | 22.07 | 1.29 | 17.12 |
| hsa-miR-128 | 23.23 | 1.98 | 11.73 |
| hsa-miR-9-5p | 24.48 | 2.17 | 11.28 |
| hsa-miR-374b-5p | 12.50 | 1.18 | 10.62 |
| hsa-miR-28-5p | 12.96 | 1.24 | 10.48 |
| Ratio (MN)/ratio (NC) = 1 | |||
| hsa-miR-378b | 100.00 | 99.55 | 1.00 |
| hsa-miR-23c | 100.00 | 99.67 | 1.00 |
| hsa-miR-378f | 100.00 | 99.72 | 1.00 |
| hsa-miR-378h | 100.00 | 99.76 | 1.00 |
| hsa-miR-378i | 100.00 | 99.99 | 1.00 |
| hsa-miR-1304-3p | 100.00 | 100.00 | 1.00 |
| Ratio (MN)/ratio (NC) <1 | |||
| hsa-miR-378g | 98.85 | 99.82 | 0.99 |
| hsa-let-7e-5p | 94.69 | 96.50 | 0.98 |
| hsa-miR-19a-3p | 78.09 | 81.60 | 0.96 |
| hsa-miR-423-5p | 0.87 | 0.92 | 0.95 |
| hsa-miR-30e-3p | 80.45 | 85.25 | 0.94 |
| hsa-miR-421 | 10.64 | 11.48 | 0.93 |
a
Percentage of miRNA base edits in MN samples.
b
Percentage of miRNA base edits in NC samples.
Ratio (MN) and ratio (NC) are the values of a and b, respectively; c was used to make the comparison between a and b. If c >1, the base edit was more common in MN samples; if c = 1, the base edit was equivalent in MN and NC samples; if c <1, the base edit was more common in NC samples. miRNA, microRNA; MN, membranous nephropathy; NC, normal controls.