Figure 1. A soluble form of HSV gH/gL binds soluble αvβ6- and αvβ8–integrin at high affinity.

(A and C) Surface Plasmon Resonsance spectroscopy was performed to evaluate binding of different concentrations of gH/gL, as indicated, to immobilized αvβ6-integrin (A) and αvβ8-integrin (C). (B and D) Linear plots of k _obs versus gH/gL concentration for the gH/gL interaction with αvβ6-integrin (B) and αvβ8-integrin (D). The intersection points with the Y axes correspond to the dissociation rates constants k_off and the slopes to the association rate constants k_on. Three independent experiments were performed for each integrin and results were plotted together without normalizing.