Figure 1. Perturbation cell biology.

Perturbing cancer cells with targeted drugs singly and in pairs (A) reveals context-specific response to therapies and illuminates protein interactions. We construct dynamic mathematical models of the cells' response to drugs that have both quantitative parameters (B) and a qualitative network interpretation (C). We use an inference algorithm called Belief Propagation (BP) to construct a set of good, i.e., predictive models (D).