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. 2013 Dec 19;8(12):e82683. doi: 10.1371/journal.pone.0082683

Figure 3. F508del bone marrow-derived cells, specifically neutrophils, play an important role in mediating thrombocytopenia.

Figure 3

A–B. Wildtype mice were irradiated and then reconstituted with wildtype or F508del bone marrow to create chimeric mice. At 24 h after LPS challenge, wildtype mice receiving F508del bone marrow developed thrombocytopenia (A) (N = 9 in each group) with higher plasma TXB2 levels (B) (N = 5 in each group) compared to wildtype mice receiving wildtype marrow. C–D. Wildtype mice were given anti-Gr-1 antibody to deplete neutrophils and then reconstituted with either wildtype or F508del neutrophils. 24 h after LPS challenge, wildtype mice receiving F508del neutrophils developed thrombocytopenia (C) and had higher levels of plasma TXB2 (D). N = 5 in each group. Data were analyzed by t-test and presented in mean ± SD. P values are listed on each panel.