Table 2. Model parameters.
Parameter | Value | Reference |
l (length of astrocyte) | ||
(K+ diffusion constant) | [31], [36], [37] | |
(Na+ diffusion constant) | [31], [36], [37] | |
(Cl− diffusion constant) | [31], [36], [37] | |
(intracellular tortuosity) | 3.2 | [12] |
(extracellular tortuosity) | 1.6 | [12] |
(specific membrane capacitance) | [38] | |
(baseline K+-conductance) | [38] | |
(baseline Na+-conductance) | [38] | |
(baseline Cl–conductance) | [38] | |
(maximum Na+/K+ pump-rate) | [20] | |
(-threshold for Na+/K+ pump) | [20] | |
(-threshold for Na+/K+ pump) | [20] | |
(initial ECS K+-concentration) | * | [20] |
(initial ICS K+-concentration) | * | [20] |
(initial ECS Na+-concentration) | * | [20] |
(initial ICS Na+-concentration) | * | [20] |
(initial ECS Cl–concentration) | * | [20] |
(initial ICS Cl–concentration) | * | [20] |
* (initial membrane potential) | [20] | |
† (decay factor for ) | [54] | |
(constant input in input zone) |
Initial concentrations are given as + Correction, where the sum gives the baseline (resting) concentration in the default parametrization of the model.
†The maximum average Na+/K+-pump rate for a single neuron was estimated to [54]. We obtained by solving , assuming that .