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. 2013 Dec 19;8(12):e84147. doi: 10.1371/journal.pone.0084147

Figure 8. Location of mutation in the second zinc binding domain of EZH2-SET.

Figure 8

EZH2-SET (cyan) is represented as a ribbon diagram with zinc atoms shown as gray spheres and side chain represented as sticks (carbon, cyan; nitrogen, blue; sulfur, sienna) A C571Y mutation was identified in MF [31] and a C576W mutation was identified in MDS [20]. These mutations disrupt coordination of zinc in the second zinc binding domain likely destabilizing the protein. Additionally, a P577L mutation was observed in ETP ALL [26].