Table 2.

Myocardial responses to intranasal cocaine

	Baseline	Cocaine
Myocardial contrast echocardiography
Myocardial A, a.u	134 ± 5	112 ± 8*
Myocardial β, s-1	0.8 ± 0.1	0.7 ± 0.1
Myocardial perfusion (A·β), a.u.·s-1	104 ± 10	76 ± 11*
Myocardial conductance, a.u.·mmHg-1	1.5 ± 0.2	0.9 ± 0.2*
Hemodynamics
Heart rate, beats·min-1	65 ± 2	73 ± 3*
Systolic Blood Pressure, mmHg	111 ± 3	125 ± 4*
Diastolic Blood Pressure, mmHg	53 ± 2	67 ± 2*
Mean Blood Pressure, mmHg	72 ± 2	86 ± 3*
LV End-diastolic volume, mL	152 ± 7	158.3 ± 7.4
LV End-systolic volume, mL	56 ± 4	53 ± 3
LV Stroke volume, mL	96 ± 5	105 ± 7*
Indices of LV work, function and oxygen demand
LV Ejection Fraction, %	64 ± 1	66 ± 2
LV end-systolic elastance, mmHg·mL-1	1.9 ± 0.2	2.5 ± 0.3*
LV end-systolic wall stress, 103 dyn/cm2	0.7 ± 0.1	0.8 ± 0.1
LV stroke work (×10-3), mmHg·mL-1	9.6 ± 0.4	11.9 ± 0.8*
LV total work, mmHg·mL-1·bpm-1	125.6 ± 14.3	176.9 ± 17.2*
MVO2, ml·min-1	6.7 ± 0.3	8.1 ± 0.4*

Data reported as mean ± SEM.

^*P < 0.05.

RBC, red blood cell; LV, left ventricle; MVO₂, myocardial oxygen consumption