Figure 2. Exercise Capacity of wild type and mutant rats.

Rats were exercised to exhaustion on a treadmill (see Materials and Methods). The running protocol was repeated twice. A. Reproducibility of measured maximal exercise capacity. The correlation of the 2 measurements was demonstrated by the large R² value, near unity of slope, and small intercept; B. Wild type and homozygote mutant rats had significantly different maximal exercise capacity, defined as time to exhaustion. The maximal exercise capacity averaged 9.3 minutes longer in wild type rats than in mutants. P-value <0.001 was based on a T-test. Wt; wild type; Hm; Homozygous mutant; F; female; M; Male.