Figure 1. Allele frequency distribution according to mutation type.

Each box represents the 25^th to 75^th percentiles, with the median shown as a line and the mean as a cross. The whiskers represent the 5^th and 95^th percentiles. Non-parametric ANOVA (Kruskal-Wallis test) indicates significant differences in the group medians at p<0.0001 and all pairwise median comparisons were also significant (p<0.0001, Mann-Whitney non parametric test), except for frameshift vs. nonsense.