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. 2013 Dec 19;8(12):e83446. doi: 10.1371/journal.pone.0083446

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© 2013 Frade et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Based on the genotypes obtained, we performed a haplotype analysis of the rs7719175 and rs1800925 polymorphisms. Only three haplotypes were found in our study population: A) Distribution of the three main haplotype combinations in the CCC patients and ASY subjects: homozygous rs640249C-rs641563C (black bar); heterozygous rs640249C-rs641563C + rs640249A-rs641563A (gray bar) and homozygous rs640249A-rs641563A (white bar). B) Haplotype combinations between cases and controls, taking sex into account. C) Distribution of the three main haplotype combinations between patients with severe and moderate CCC, taking sex into account.