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. 2013 Dec 19;8(12):e83446. doi: 10.1371/journal.pone.0083446

Figure 4. The same trends for association were detected in a small, independent replication cohort.

Figure 4

The two main polymorphisms, rs640249 and rs641563, were genotyped in the independent replication cohort. This second cohort focused exclusively on male patients with Chagas disease, who have a higher risk of progression to CCC. This replication cohort included asymptomatic (n = 36) and CCC patients (n = 102). Of the 106 patients with CCC, 48 had severe ventricular dysfunction (left ventricular ejection fraction <40%). The rs640249 genotype distribution is illustrated in A. The results for the rs641563 polymorphism are in B. Haplotype analysis was then performed in C.