Table 2. Genotype distribution on asymptomatic individuals (ASY) and cases (CCC) taking into account the gender and the left ventricular ejection fraction values.
|
ASY
|
CCC
|
CCC(EF<0.4)
|
CCC(EF>0.4)
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Total | Male | Female | Total | Male | Female | Total | Male | Female | Total | Male | Female | |
| rs639735C/T | CC | 52 (44.8%) | 19 (36.5%) | 32 (50.8%) | 147 (47.9%) | 86 (46.0%) | 59 (50.0%) | 96 (49.0%) | 69 (48.6%) | 27 (50.0%) | 48 (47.1%) | 16 (40.0%) | 32 (51.6%) |
| CT | 50 (43.1%) | 28 (53.8%) | 22 (34.9%) | 134 (43.6%) | 88 (47.1%) | 46 (39.0%) | 85 (43.4%) | 64 (45.1%) | 21 (38.9%) | 44 (43.1%) | 21 (52.5%) | 23 (37.1%) | |
| TT | 14 (12.1%) | 5 (9.6%) | 9 (14.3%) | 26 (8.5%) | 13 (7.0%) | 13 (11.0%) | 15 (7.7%) | 9 (6.3%) | 6 (11.1%) | 10 (9.8%) | 3 (7.5%) | 7 (11.3%) | |
| rs640249C/A | CC | 36 (31.8%) | 14 (26.9%) | 21 (35.0%) | 115 (37.7%) | 66 (35.1%) | 48 (41.7%) | 78 (40.0%) | 57 (40.4%) | 21 (38.9%) | 36 (35.6%) | 9 -0,22 | 27 -0,45 |
| CA | 49 (43.4%) | 24 (46.2%) | 25 (41.7%) | 150 (49.2%) | 100 (53.2%) | 49 (42.6%) | 94 (48.2%) | 67 (47.5%) | 27 -0,5 | 49 (48.5%) | 27 (65.9%) | 22 (36.7%) | |
| AA | 28 (24.8%) | 14 (26.9%) | 14 (23.3%) | 40 (13.1%) | 22 (11.7%) | 18 (15.7%) | 23 (11.8%) | 17 (12.1%) | 6 (11.1%) | 16 (15.8%) | 5 (12.2%) | 11 (18.3%) | |
| rs893130A/T | AA | 91 (77.8%) | 38 (73.1%) | 52 (81.3%) | 230 (73.7%) | 144 (75.4%) | 85 (71.4%) | 145 (73.2%) | 108 (75.0%) | 37 (68.5%) | 76 (73.1%) | 37 (68.5%) | 30 (73.2%) |
| AT | 24 (20.5%) | 14 (26.9%) | 10 (15.6%) | 74 (23.7%) | 43 (22.5%) | 30 (25.2%) | 48 (24.2%) | 32 (22.2%) | 16 (29.6%) | 25 -0,24 | 16 (29.6%) | 11 (26.6%) | |
| TT | 2 (1.7%) | 0 (0.0%) | 2 (3.1%) | 8 (2.6%) | 4 (2.1%) | 4 (3.4%) | 5 (2.5%) | 4 (2.8%) | 1 (1.9%) | 3 (2.9%) | 1 (1.9%) | 0 (0.0%) | |
| rs475786C/G | CC | 89 (85.6%) | 40 (87.0%) | 48 (84.2%) | 209 (77.7%) | 132 (81.0%) | 76 (72.4%) | 133 (77.8%) | 98 (81.0%) | 35 (70.0%) | 69 (76.7%) | 30 (81.1%) | 39 (73.6%) |
| CG | 15 (14.4%) | 6 (13.0%) | 9 (15.8%) | 59 (21.9%) | 30 (18.4%) | 29 (27.6%) | 37 (21.6%) | 22 (18.2%) | 15 (30.0%) | 21 (23.3%) | 7 (18.9%) | 14 (26.4%) | |
| GG | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (0.4%) | 1 (0.6%) | 0 (0.0%) | 1 (0.6%) | 1 (0.8%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |
| rs893131T/C | TT | 81 (68.6%) | 36 (67.9%) | 45 (70.3%) | 195 (62.7%) | 117 (61.9%) | 77 (64.2%) | 127 (64.5%) | 89 (62.7%) | 38 (69.1%) | 63 (60.6%) | 25 -0,61 | 38 (60.3%) |
| TC | 34 (28.8%) | 16 (30.2%) | 17 (26.6%) | 98 (31.5%) | 62 (32.8%) | 35 (29.2%) | 59 (29.9%) | 45 (31.7%) | 14 (25.5%) | 35 (33.7%) | 14 (34.1%) | 21 (33.3%) | |
| CC | 3 (2.5%) | 1 (1.9%) | 2 (3.1%) | 18 (5.8%) | 10 (5.3%) | 8 (6.7%) | 11 (5.6%) | 8 (5.6%) | 3 (5.5%) | 6 (5.8%) | 2 (4.9%) | 4 (6.3%) | |
| rs893132T/C | T/T | 60 (54.5%) | 26 (54.2%) | 33 (54.1%) | 186 (60.6%) | 111 (59.0%) | 73 (62.4%) | 121 (62.1%) | 86 (61.0%) | 35 (64.8%) | 59 (57.3%) | 23 (54.8%) | 36 (59.0%) |
| T/C | 42 (38.2%) | 17 (35.4%) | 25 (41.0%) | 107 (34.9%) | 64 (34.0%) | 43 (36.8%) | 66 (33.8%) | 47 (33.3%) | 19 (35.2%) | 39 (37.9%) | 15 (35.7%) | 24 (39.3%) | |
| C/C | 8 (7.3%) | 5 (10.4%) | 3 (4.9%) | 14 (4.6%) | 13 (6.9%) | 1 (0.9%) | 8 (4.1%) | 8 (5.7%) | 0 (0.0%) | 5 (4.9%) | 4 (9.5%) | 1 (1.6%) | |
| rs533225A/T | AA | 90 (86.5%) | 41 (89.1%) | 48 (84.2%) | 207 (84.5%) | 132 (87.4%) | 74 (79.6%) | 134 (86.5%) | 96 (88.1%) | 38 (75.6%) | 66 (79.5%) | 32 (84.2%) | 34 (75.6%) |
| AT | 13 (12.5%) | 5 (10.9%) | 8 -0,14 | 35 (14.3%) | 19 (12.6%) | 16 (17.2%) | 19 (12.3%) | 13 (11.9%) | 10 (22.2%) | 16 (19.3%) | 6 (15.8%) | 10 (22.2%) | |
| TT | 1 (1.0%) | 0 (0.0%) | 1 (1.8%) | 3 (1.2%) | 0 (0.0%) | 3 (3.2%) | 2 (1.3%) | 0 (0.0%) | 1 (2.2%) | 1 (1.2%) | 0 (0.0%) | 1 (2.2%) | |
| rs670957G/A | GG | 36 (32.1%) | 16 (32.7%) | 20 (32.3%) | 80 (26.1%) | 50 (26.6%) | 30 (25.9%) | 46 (23.4%) | 34 (23.8%) | 12 (22.2%) | 33 (32.7%) | 15 (37.5%) | 18 (29.5%) |
| GA | 51 (45.5%) | 22 (44.9%) | 29 (46.8%) | 149 (48.7%) | 89 (47.3%) | 58 (50.0%) | 103 (52.3%) | 71 (49.7%) | 32 (59.3%) | 40 (39.6%) | 15 (37.5%) | 25 (41.0%) | |
| AA | 25 (22.3%) | 11 (22.4%) | 13 -0,21 | 77 (25.2%) | 49 (26.1%) | 28 (24.1%) | 48 (24.4%) | 38 (26.6%) | 10 (18.5%) | 28 (27.9%) | 10 (25.0%) | 18 (29.5%) | |
| rs525720G/A | GG | 50 (68.5%) | 25 (80.6%) | 25 -0,61 | 189 -0,75 | 113 (73.4%) | 74 (77.1%) | 118 (73.8%) | 83 (72.2%) | 35 (77.8%) | 64 (75.3%) | 26 (74.3%) | 38 (76.0%) |
| GA | 20 (27.4%) | 5 (16.1%) | 14 (34.1%) | 60 (23.8%) | 38 (24.7%) | 22 (22.9%) | 41 (25.6%) | 31 (27.0%) | 10 (22.2%) | 19 (22.4%) | 7 (20.0%) | 12 (24.0%) | |
| AA | 3 (4.1%) | 1 (3.2%) | 2 (4.9%) | 3 (1.2%) | 3 (1.9%) | 0 (0.0%) | 1 (0.6%) | 1 (0.9%) | 0 (0.0%) | 2 (2.4%) | 2 (5.7%) | 0 (0.0%) | |
| rs7166484G/A | GG | 44 (39.6%) | 21 (42.0%) | 22 (36.7%) | 101 (32.4%) | 54 (28.3%) | 46 (38.7%) | 55 (27.6%) | 36 -0,25 | 19 (34.5%) | 42 (40.8%) | 16 (39.0%) | 26 (41.9%) |
| GA | 50 (45.0%) | 20 (40.0%) | 30 (50.0%) | 158 (50.6%) | 105 (55.0%) | 52 (43.7%) | 108 (54.3%) | 80 (55.6%) | 28 (50.9%) | 44 (42.7%) | 21 (51.2%) | 23 (37.1%) | |
| AA | 17 (15.3%) | 9 (18.0%) | 8 (13.3%) | 53 (17.0%) | 32 (16.8%) | 21 (17.6%) | 36 (18.1%) | 28 (19.4%) | 8 (14.5%) | 17 (16.5%) | 4 (9.8%) | 13 (21.0%) | |
| rs2070664A/G | AA | 42 (36.8%) | 16 (30.8%) | 25 (41.0%) | 123 (39.9%) | 71 (38.0%) | 51 (42.9%) | 65 (33.2%) | 46 (32.6%) | 19 (34.5%) | 53 (51.5%) | 21 (52.5%) | 32 (50.8%) |
| AG | 61 (53.5%) | 33 (63.5%) | 28 (45.9%) | 143 (46.4%) | 90 (48.1%) | 52 (43.7%) | 102 -0,52 | 73 (51.8%) | 29 (52.7%) | 38 (36.9%) | 15 (37.5%) | 23 (36.5%) | |
| GG | 11 (9.6%) | 3 (5.8%) | 8 (13.1%) | 42 (13.6%) | 26 (13.9%) | 16 (13.4%) | 29 (14.8%) | 22 (15.6%) | 7 (12.7%) | 12 (11.7%) | 4 (10.0%) | 8 (12.7%) | |
| rs3729755G/C | GG | 71 (62.3%) | 31 (59.6%) | 39 (63.9%) | 175 (55.9%) | 104 (54.5%) | 70 (58.3%) | 113 (56.8%) | 80 (55.6%) | 33 (57.1%) | 57 (54.8%) | 21 (51.2%) | 36 (57.1%) |
| GC | 35 (30.7%) | 17 (32.7%) | 18 (29.5%) | 121 (38.7%) | 79 (41.4%) | 41 (34.2%) | 77 (38.7%) | 58 (40.3%) | 19 (34.5%) | 39 (37.5%) | 18 (40.3%) | 21 (33.3%) | |
| CC | 8 -0,07 | 4 (7.7%) | 4 (6.6%) | 17 (5.4%) | 8 (4.2%) | 9 (7.5%) | 9 (4.5%) | 6 (4.2%) | 3 (5.5%) | 8 (7.7%) | 2 (4.9%) | 6 (9.5%) | |
| rs533021G/A | GG | 23 (23.7%) | 10 (22.2%) | 13 -0,25 | 84 (29.1%) | 56 (31.5%) | 28 (25.7%) | 57 (30.3%) | 42 (31.1%) | 15 (28.3%) | 26 -0,28 | 14 (36.8%) | 12 (21.8%) |
| GA | 55 (56.7%) | 28 (62.7%) | 27 (51.9%) | 136 (47.1%) | 86 (48.3%) | 48 (44.0%) | 85 (45.2%) | 63 (46.7%) | 22 (41.5%) | 45 (48.4%) | 19 -0,5 | 26 (47.3%) | |
| AA | 19 (19.6%) | 7 (15.6%) | 12 (23.1%) | 69 (23.9%) | 36 (20.2%) | 33 (30.3%) | 46 (24.5%) | 30 (22.2%) | 16 (30.2%) | 22 (23.7%) | 5 (13.2%) | 17 (30.9%) | |
| rs492038T/G | TT | 38 (33.9%) | 15 (30.6%) | 23 (37.1%) | 87 (28.3%) | 48 (25.8%) | 37 (31.1%) | 59 (30.3%) | 42 (30.0%) | 17 (30.9%) | 23 (22.3%) | 4 (9.8%) | 19 (30.6%) |
| TG | 49 (43.8%) | 23 (46.9%) | 25 (40.3%) | 156 (50.8%) | 96 (51.6%) | 60 (50.4%) | 94 (48.2%) | 65 (47.1%) | 28 (50.9%) | 58 (56.3%) | 27 (65.9%) | 31 (50.0%) | |
| GG | 25 (22.3%) | 11 (22.4%) | 14 (22.6%) | 64 (20.8%) | 42 (22.6%) | 22 (18.5%) | 42 (21.5%) | 32 (22.9%) | 10 (18.2%) | 22 (21.4%) | 10 (24.4%) | 12 (19.4%) | |
| rs4924215G/A | GG | 67 (59.8%) | 28 (56.0%) | 39 (63.9%) | 160 (51.4%) | 103 (54.5%) | 57 (47.5%) | 102 (51.5%) | 79 (55.2%) | 23 (41.8%) | 54 (52.4%) | 20 -0,5 | 34 -0,54 |
| GA | 41 (36.6%) | 20 (40.0%) | 20 (32.8%) | 120 (38.6%) | 69 (36.5%) | 50 (41.7%) | 79 (39.9%) | 51 (35.7%) | 28 (50.9%) | 37 (35.9%) | 17 (42.5%) | 20 (31.7%) | |
| AA | 4 (3.6%) | 2 (4.0%) | 2 (3.3%) | 31 -0,1 | 17 (9.0%) | 13 (10.8%) | 17 (8.6%) | 13 (9.1%) | 4 (7.3%) | 12 (11.7%) | 3 (7.5%) | 9 (14.3%) | |
| rs4924214T/C | TT | 56 (52.8%) | 26 (58.5%) | 30 (50.8%) | 165 (54.6%) | 94 (51.4%) | 69 (59.0%) | 101 (52.3%) | 70 (50.7%) | 31 (56.4%) | 57 (56.4%) | 20 -0,5 | 37 (60.7%) |
| TC | 44 (41.5%) | 17 -0,37 | 26 (44.1%) | 113 (37.4%) | 74 (40.4%) | 39 (33.3%) | 74 (38.3%) | 55 (39.9%) | 19 (34.5%) | 38 (37.6%) | 18 (45.0%) | 20 (32.8%) | |
| CC | 6 (5.7%) | 3 (6.5%) | 3 (5.1%) | 24 (7.9%) | 15 (8.2%) | 9 (7.7%) | 18 (9.3%) | 13 (9.4%) | 5 (9.1%) | 6 (5.9%) | 2 (5.0%) | 4 (6.6%) | |
| rs7179902A/T | AA | 80 (71.4%) | 39 (76.5%) | 41 (68.3%) | 215 (69.4%) | 136 (72.0%) | 78 (65.5%) | 138 (70.1%) | 104 (73.2%) | 34 (61.8%) | 71 (68.9%) | 28 (68.3%) | 43 (69.4%) |
| AT | 29 (25.9%) | 11 (21.6%) | 17 (28.3%) | 80 (25.8%) | 45 (23.8%) | 34 (28.6%) | 50 (25.4%) | 32 (22.5%) | 18 (32.7%) | 26 (25.2%) | 11 (26.8%) | 15 (24.2%) | |
| TT | 3 (2.7%) | 1 (2.0%) | 2 (3.3%) | 15 (4.8%) | 8 (4.2%) | 7 (5.9%) | 9 (4.5%) | 6 (4.2%) | 3 (5.5%) | 6 (5.8%) | 2 (4.9%) | 4 (6.5%) | |
The rs1851317 marker was not informative in our study population.