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. 2013 Dec 19;8(12):e84543. doi: 10.1371/journal.pone.0084543

Figure 3. Prefrontal-entorhinal disconnection did not impair memory expression in delay eyeblink conditioning.

Figure 3

A, During delay eyeblink conditioning sessions, the rats received the conditioned stimulus (CS; 350 ms tone) which co-terminated with the unconditioned stimulus (US; 100 ms periorbital shock). An increase in EMG activity before US onset was defined as a conditioned response (CR; black marking). B, After retention sessions, the Remote group was trained in delay eyeblink conditioning. The rats acquired the association in one session (grey bar), and the CR expression (CR %) was comparable after either artificial cerebral spinal fluid (aCSF; white bar) or muscimol (Mus; black bar) infusions into the prelimbic prefrontal cortex (PrL) and lateral entorhinal cortex (LEC). C, The increase in CR amplitude following CS onset was similar after aCSF or muscimol infusions.