(A) Experimental design from 6 to 19 weeks of age. All mice were subjected to repeated assessments of behaviors, alongside in
vivo MRI taken at 9 and 17 weeks of age. At 19 weeks of age all mice were culled and an ex
vivo MRI scan was taken. STM = swimming T-maze; GS = grip strength; OF = locomotor activity in an open field, OD = odor discrimination, SI = social interaction, RR = rotarod, FC = cued and contextual fear conditioning. Body weight gain for both male (B) and female mice (C). Body weight analyzed using three-way ANOVA (Genotype X Gender X Age). Body weight: WT male n=11, R6/1 male n=9, WT female n=10, R6/1 female n=10-8. All data presented as means ± SEM; *p<0.05.