Table 3. Multivariable Cox porportional hazards regression results of the associations between physical activity and sedentary behavior in relation to esophageal and gastric cancers.
| Variable | Exposure Level |
ESCC
|
EA
|
GCA
|
GNCA
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P Value | HR (95%CI) | P Value | HR (95%CI) | P Value | HR (95%CI) | P Value | |||||
| Baseline Questionnaire | ||||||||||||
| Current daily routine at work | All day sitting | Referent | Referent | Referent | Referent | |||||||
| Mostly sitting | 1.08 (0.63, 1.84) | 0.78 | 0.89 (0.65, 1.20) | 0.43 | 1.18 (0.80, 1.75) | 0.40 | 0.90 (0.62, 1.31) | 0.58 | ||||
| Walking, minimal lifting | 0.91 (0.53, 1.55) | 0.73 | 0.83 (0.61, 1.12) | 0.22 | 1.27 (0.86, 1.88) | 0.23 | 1.02 (0.71, 1.47) | 0.92 | ||||
| Lift light loads, climb stairs | 0.73 (0.40, 1.35) | 0.32 | 0.90 (0.65, 1.26) | 0.54 | 1.02 (0.66, 1.59) | 0.92 | 0.69 (0.45, 1.05) | 0.08 | ||||
| Heavy work | 0.73 (0.27, 2.01) | 0.55 | 0.60 (0.34, 1.07) | 0.08 | 1.77 (1.01, 3.09) | 0.05 | 0.98 (0.54, 1.78) | 0.95 | ||||
| p-trend | 0.09 | 0.25 | 0.43 | 0.26 | ||||||||
| Strenuous physical activity during last 12 months | Never | Referent | Referent | Referent | Referent | |||||||
| Rarely | 0.76 (0.42, 1.37) | 0.36 | 0.83 (0.54, 1.26) | 0.38 | 0.66 (0.42, 1.03) | 0.07 | 0.76 (0.51, 1.14) | 0.18 | ||||
| 1–3 times/month | 0.62 (0.33, 1.16) | 0.13 | 0.77 (0.50, 1.18) | 0.23 | 0.76 (0.49, 1.19) | 0.23 | 0.64 (0.42, 0.98) | 0.04 | ||||
| 1–2 times/week | 0.60 (0.33, 1.08) | 0.09 | 0.86 (0.57, 1.28) | 0.45 | 0.72 (0.47, 1.10) | 0.13 | 0.64 (0.43, 0.94) | 0.02 | ||||
| 3–4 times/week | 0.73 (0.41, 1.29) | 0.28 | 0.87 (0.59, 1.30) | 0.50 | 0.68 (0.44, 1.04) | 0.07 | 0.60 (0.41, 0.89) | 0.01 | ||||
| >5 times/week | 0.84 (0.47, 1.52) | 0.56 | 0.74 (0.49, 1.12) | 0.15 | 0.71 (0.46, 1.10) | 0.12 | 0.58 (0.39, 0.88) | 0.01 | ||||
| p-trend | 1.00 | 0.47 | 0.41 | 0.01 | ||||||||
| Typical physical activity and sports during ages 15–18 years | Never | Referent | Referent | Referent | Referent | |||||||
| Rarely | 0.49 (0.19, 1.27) | 0.14 | 0.57 (0.28, 1.14) | 0.11 | 0.68 (0.31, 1.49) | 0.34 | 0.82 (0.43, 1.60) | 0.57 | ||||
| 1-3 times/month | 0.48 (0.18, 1.29) | 0.15 | 0.89 (0.45, 1.76) | 0.74 | 0.81 (0.37, 1.76) | 0.59 | 0.83 (0.42, 1.65) | 0.60 | ||||
| 1-2 times/week | 0.55 (0.23, 1.33) | 0.19 | 0.60 (0.31, 1.16) | 0.13 | 0.53 (0.25, 1.12) | 0.10 | 0.81 (0.43, 1.53) | 0.51 | ||||
| 3-4 times/week | 0.49 (0.21, 1.15) | 0.10 | 0.63 (0.33, 1.19) | 0.15 | 0.66 (0.32, 1.36) | 0.26 | 0.74 (0.39, 1.37) | 0.33 | ||||
| >5 times/week | 0.53 (0.23, 1.23) | 0.14 | 0.57 (0.30, 1.07) | 0.08 | 0.67 (0.33, 1.37) | 0.28 | 0.62 (0.34, 1.15) | 0.13 | ||||
| p-trend | 0.75 | 0.07 | 0.74 | 0.01 | ||||||||
| Risk Factor Questionnaire | ||||||||||||
| Typical recreational moderate-vigorous physical activity during ages 15–18 years | Never | Referent | Referent | Referent | Referent | |||||||
| <1 hour/week | 0.75 (0.30, 1.85) | 0.53 | 0.81 (0.43, 1.53) | 0.51 | 0.63 (0.29, 1.38) | 0.25 | 0.81 (0.46, 1.43) | 0.46 | ||||
| 1-3 hours/week | 0.96 (0.50, 1.85) | 0.91 | 1.03 (0.65, 1.64) | 0.90 | 0.76 (0.44, 1.33) | 0.34 | 0.80 (0.52, 1.24) | 0.32 | ||||
| 4-7 hours/week | 0.74 (0.38, 1.44) | 0.38 | 1.22 (0.79, 1.90) | 0.37 | 0.98 (0.58, 1.63) | 0.92 | 0.79 (0.52, 1.21) | 0.28 | ||||
| >7 hours/week | 0.77 (0.42, 1.39) | 0.38 | 1.08 (0.71, 1.63) | 0.73 | 1.11 (0.70, 1.77) | 0.66 | 0.61 (0.41, 0.91) | 0.01 | ||||
| p-trend | 0.34 | 0.46 | 0.11 | 0.01 | ||||||||
| Typical recreational moderate-vigorous physical activity during ages 19–29 years | Never | Referent | Referent | Referent | Referent | |||||||
| <1 hour/week | 1.14 (0.45, 2.89) | 0.78 | 0.97 (0.55, 1.71) | 0.91 | 0.83 (0.42, 1.62) | 0.59 | 0.83 (0.48, 1.43) | 0.50 | ||||
| 1-3 hours/week | 1.47 (0.70, 3.09) | 0.31 | 1.18 (0.75, 1.85) | 0.48 | 1.05 (0.63, 1.77) | 0.85 | 0.76 (0.49, 1.18) | 0.23 | ||||
| 4-7 hours/week | 1.11 (0.52, 2.34) | 0.79 | 1.48 (0.96, 2.28) | 0.07 | 1.24 (0.76, 2.03) | 0.40 | 0.76 (0.49, 1.16) | 0.20 | ||||
| >7 hours/week | 1.17 (0.57, 2.41) | 0.67 | 1.02 (0.66, 1.57) | 0.95 | 1.00 (0.61, 1.64) | 0.99 | 0.73 (0.48, 1.11) | 0.14 | ||||
| p-trend | 0.96 | 0.83 | 0.71 | 0.17 | ||||||||
| Typical recreational moderate-vigorous physical activity during ages 35–39 years | Never | Referent | Referent | Referent | Referent | |||||||
| <1 hour/week | 1.42 (0.57, 3.54) | 0.45 | 0.87 (0.54, 1.40) | 0.57 | 0.91 (0.53, 1.56) | 0.73 | 0.60 (0.36, 1.03) | 0.07 | ||||
| 1-3 hours/week | 1.82 (0.84, 3.94) | 0.13 | 1.01 (0.69, 1.48) | 0.97 | 0.86 (0.55, 1.35) | 0.51 | 0.72 (0.48, 1.07) | 0.10 | ||||
| 4-7 hours/week | 1.52 (0.70, 3.31) | 0.29 | 1.13 (0.77, 1.64) | 0.53 | 1.00 (0.64, 1.56) | 0.99 | 0.66 (0.44, 0.99) | 0.04 | ||||
| >7 hours/week | 1.59 (0.73, 3.43) | 0.24 | 0.92 (0.62, 1.36) | 0.67 | 0.92 (0.58, 1.44) | 0.71 | 0.75 (0.50, 1.12) | 0.16 | ||||
| p-trend | 0.46 | 0.94 | 0.98 | 0.33 | ||||||||
| Typical recreational moderate-vigorous physical activity in the last ten-years | Never | Referent | Referent | Referent | Referent | |||||||
| <1 hour/week | 1.30 (0.68, 2.47) | 0.43 | 0.92 (0.61, 1.39) | 0.69 | 1.31 (0.82, 2.11) | 0.26 | 0.71 (0.43, 1.19) | 0.19 | ||||
| 1-3 hours/week | 0.85 (0.48, 1.53) | 0.59 | 0.97 (0.69, 1.36) | 0.86 | 1.14 (0.75, 1.72) | 0.55 | 0.90 (0.61, 1.32) | 0.59 | ||||
| 4-7 hours/week | 0.98 (0.55, 1.73) | 0.94 | 1.05 (0.75, 1.47) | 0.77 | 1.15 (0.76, 1.75) | 0.51 | 0.92 (0.63, 1.36) | 0.68 | ||||
| >7 hours/week | 0.88 (0.49, 1.58) | 0.66 | 0.98 (0.69, 1.39) | 0.91 | 1.00 (0.65, 1.56) | 0.99 | 0.83 (0.56, 1.24) | 0.36 | ||||
| p-trend | 0.50 | 0.84 | 0.81 | 0.65 | ||||||||
| Typical number of hours per day watching TV during last 12 months | <1 hour/day | Referent | Referent | Referent | Referent | |||||||
| 1-2 hours/day | 0.98 (0.43, 2.23) | 0.97 | 0.65 (0.42, 1.01) | 0.05 | 0.93 (0.47, 1.84) | 0.83 | 1.05 (0.56, 1.94) | 0.89 | ||||
| 3-4 hours/day | 0.79 (0.35, 1.78) | 0.57 | 0.55 (0.36, 0.84) | 0.01 | 1.32 (0.69, 2.53) | 0.41 | 1.19 (0.65, 2.17) | 0.57 | ||||
| 5-6 hours/day | 1.21 (0.52, 2.85) | 0.66 | 0.57 (0.36, 0.92) | 0.02 | 1.23 (0.61, 2.48) | 0.57 | 0.99 (0.51, 1.92) | 0.98 | ||||
| >7 hours/day | 0.78 (0.26, 2.32) | 0.66 | 0.55 (0.29, 1.01) | 0.05 | 1.36 (0.60, 3.06) | 0.46 | 0.94 (0.42, 2.11) | 0.88 | ||||
| p-trend | 0.88 | 0.09 | 0.11 | 0.85 | ||||||||
| Typical number of hours per day sitting during last 12 months | <3 hours/day | Referent | Referent | Referent | Referent | |||||||
| 3-4 hours/day | 0.81 (0.47, 1.39) | 0.44 | 1.06 (0.78, 1.45) | 0.70 | 0.70 (0.49, 1.01) | 0.06 | 1.10 (0.78, 1.56) | 0.57 | ||||
| 5-6 hours/day | 1.10 (0.66, 1.83) | 0.72 | 1.11 (0.82, 1.51) | 0.51 | 0.79 (0.55, 1.13) | 0.20 | 0.97 (0.68, 1.40) | 0.88 | ||||
| 7-8 hours/day | 1.03 (0.56, 1.90) | 0.92 | 1.03 (0.71, 1.49) | 0.88 | 0.67 (0.43, 1.05) | 0.08 | 1.05 (0.68, 1.61) | 0.83 | ||||
| >9 hours/day | 0.87 (0.40, 1.90) | 0.72 | 0.69 (0.41, 1.15) | 0.15 | 1.00 (0.62, 1.61) | 1.00 | 0.82 (0.46, 1.47) | 0.51 | ||||
| p-trend | 0.78 | 0.36 | 0.63 | 0.55 | ||||||||