Table 2.
Summary of changes in anxiety levels occurring after pharmacological activation and genetic inactivation of MT2 receptors
Factor | Pharmacological studies with UCM765 | Genetic inactivation of MT2 receptors |
---|---|---|
Elevated plus maze test | ||
Open arm entries | ↔ | ↔ |
Open arm time | ↑ | ↔ |
Novelty suppressed feeding test | ||
Latency to eat in a new environment | ↓ | ↑ |
Latency to eat in the home cage | ↔ | ↔ |
Open field test | ||
Locomotion | ↔ | ↔ |
Number of entries in the central area | ↔ | ↑* |
Time spent in the central area | ↔ | ↑* |
↑ = increase; ↔ = no change; ↓= decrease.
Only during the first 5 minutes of the test session.