Table 2.

Summary of changes in anxiety levels occurring after pharmacological activation and genetic inactivation of MT₂ receptors

Factor	Pharmacological studies with UCM765	Genetic inactivation of MT2 receptors
Elevated plus maze test
Open arm entries	↔	↔
Open arm time	↑	↔
Novelty suppressed feeding test
Latency to eat in a new environment	↓	↑
Latency to eat in the home cage	↔	↔
Open field test
Locomotion	↔	↔
Number of entries in the central area	↔	↑*
Time spent in the central area	↔	↑*

↑ = increase; ↔ = no change; ↓= decrease.

^*Only during the first 5 minutes of the test session.