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. 2013 Nov 18;5(11):825–834. doi: 10.18632/aging.100615

Figure 4.

Figure 4

Keratinization of the meibomian gland orifice. (A-C) A 5month and (D-F) 2year old mouse lid margin cross-sections. (D) Gland plugging and (D-F) a loss of CK1+ cells posterior to the orifice causes the mucocutaneous junction to shift anteriorly in the aged mouse eyelid. CK1 immunostaining shows no hyper-keratinization or obstruction in the atrophic meibomian glands.