Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Nov 18;5(11):825–834. doi: 10.18632/aging.100615

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2013 Parfitt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

PMC Copyright notice

Nascent acini and their absence with aging. (A) A 3-D reconstruction of the 5 month old meibomian gland and an orthoslice taken at the region of interest: the transition between duct and acini (yellow arrowhead). (B) An acinus with a significant CK6⁺ component (C) also exhibits localized proliferation in the same region, according to Ki67 staining (D) and the resulting overlay (E). (F) The 3-D reconstruction of a 2 year meibomian gland with ductal truncation was evaluated at the same transitional region between duct and multiple acini (G - red arrowheads) and no prominent CK6 (H) or (I) Ki67 staining was evident when overlaying the sequential immunostains (J), suggesting a loss of proliferation in these zones.