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Summary model of interactions involved in the formation of the non-covalent PIAS E3·SUMO·UBC9 E2 ternary complex. In our model SUMO bridges the non-covalent ternary complex by simultaneously interacting with the phospho-SIM motif of PIAS1 via its SIM binding region (SBR) and with the backside of UBC9 through its UBC9 binding region (UBR) domain. In addition, this ternary complex appears to be reinforced through interactions between PIAS1 SP-RING domain and UBC9 L4 loop.
