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Design of NoxA1ds. Alignment of p67phox and NOXA1 indicates a highly homologous region between the two sequences within the activation domain. Phe-199 (F199) in NOXA1 was previously shown to be critical for enzymatic activity of Nox1. We selected an 11-mer sequence that contained critical portions of the activation domain (i.e. Phe-199), substituted Phe-199 to Ala, and used the resulting peptide as NoxA1ds.
