FIGURE 7.

KP metabolites in brain. A, compared with wild-type (Kmo^+/+) controls, tryptophan levels are slightly reduced in the brain of Kmo^−/− mice. B, D, and E, the levels of kynurenine (B), KYNA (D), and anthranilic acid (E) are significantly elevated in Kmo^−/− mice. C, the levels of 3-HK are significantly reduced in the mutant animals. F, Kmo^−/− mice exhibit a moderate, but significant, reduction in QUIN levels compared with Kmo^+/+ controls. G, no significant differences between the levels of NAD⁺ in Kmo^+/+and Kmo^−/− genotypes. The data are the means ± S.E. (n = 6–7/group). Statistical analysis was performed using Student's t test. *, p < 0.05; ***, p < 0.001 versus Kmo^+/+.