Figure 1.

Anthropometric and food intake of WT/WT and WT/db mice on an HFD. A–C, WT male mice reconstituted with leptin receptor-deficient (WT/db) bone marrow gained significantly less weight at the end of a 16-week HFD challenge (A), with a significantly different cumulative weight gain (B) and significantly lower ratio adipose tissue pads to body weight (C) compared with controls (WT/WT). D and E, This occurred with no difference in food intake (D) and significantly different energy efficiency between groups (E). *, P < .05. Abbreviations: BAT, brown AT; rpWAT, retroperitoneal WAT.