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. 2014 Jan;28(1):176–194. doi: 10.1096/fj.13-232629

Figure 2.

Figure 2.

Effects of CSE on the amplitude and period of PER2::LUC expression in lung and SCN tissue explants. A) PER2::LUC expression in representative lung tissue explants treated with medium alone (controls). Treatment at the time of culture with CSE at 0.1 and 0.25% significantly and dose dependently dampened the rhythm of PER2::LUC expression in lung tissue. Treatment with CSE dose dependently increased the period of PER2::LUC expression in lung explants (control, 24±0.25; 0.1% CSE, 26.21±0.37; 0.25% CSE, 27.79±1.24). B) PER2::LUC expression rhythms in representative hemi-SCN tissue explants treated with medium alone (controls). Treatment with 0.1% CSE did not reduce the amplitude of PER2::LUC expression in SCN explants, but 0.1% CSE significantly shortened the period of PER2::LUC expression in the SCN when compared with controls (controls, 26±0.43 vs. 0.1% CSE, 24.42±0.20). Each line represents tissue from different animals. Data from control and CSE treatment represent means ± se (n=4–6/group). *P < 0.05, **P < 0.01 vs. corresponding untreated control (medium alone).