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In vitro Matrigel cord formation is inhibited by Akt3 knockdown or by CRM-1 overexpression. HUVECs were transfected with scrambled control (SCR), Akt3 RNAi (Akt3i), or CRM-1 for 48 h, plated on Matrigel, and allowed to incubate for 6 h. A) Representative phase-contrast images. B) Quantitation of branch points. *P < 0.05.
