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. 2014 Jan;348(1):106–115. doi: 10.1124/jpet.113.208538

Fig. 2.

Fig. 2.

Effects of pretreatment with JHW007 (A), AHN2-005 (B), AHN1-055 (C), or GBR 12909 (D) on cocaine-induced increases in locomotor activity in mice. Ordinates: horizontal locomotor activity counts/minute. Abscissae: treatment condition, vehicle (V), or cocaine dose in milligrams per kilogram. JHW007, AHN2-005, AHN1-055, or GBR 12909 were administered 4.5, 3.5, 2.5, or 2 hours before administration of different doses of cocaine (5.0–60 mg/kg). Each point represents the average (+S.E.M.) rate in counts/minute determined in six to eight mice for a time period of 90 minutes. Note that in contrast to the other N-substituted BZT analogs and GBR 12909, JHW007 dose-dependently and fully antagonized the locomotor-stimulant effects of cocaine. *P < 0.05 versus vehicle + vehicle; #P < 0.05 versus vehicle + cocaine.