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. 2014 Jan;348(1):106–115. doi: 10.1124/jpet.113.208538

Fig. 3.

Fig. 3.

Effects of pretreatment with JHW007 on increases in locomotor activity in mice produced by GBR 12909 (A) or SNC 80 (B). Ordinates: horizontal locomotor activity counts/minute. Abscissae: treatment condition, vehicle (V), GBR 12909, or SNC 80 dose in milligrams per kilograms. JHW007 (10 mg/kg) was administered 4.5 hours before administration of different doses of GBR 12909 (3.0–56 mg/kg) or SNC 80 (1.0–30 mg/kg). Each point represents the average (+ S.E.M.) rate in counts/minute determined in six to eight mice for a time period of 90 minutes. Note that JHW007 fully blocked the locomotor-stimulant effects of GBR 12909 and failed to alter the increases in locomotor activity produced by the δ-opioid agonist SNC 80. *P < 0.05 versus vehicle + vehicle; #P < 0.05 versus vehicle + GBR 12909.