Fig. 5.
Effects of pretreatment with JHW007 on cocaine-induced increases in locomotor activity in DA D2R WT and KO mice. Ordinates: horizontal locomotor activity counts/minute. Abscissae: treatment condition, vehicle (V), or cocaine dose in milligrams per kilograms. JHW007 was administered 4.5 hours before administration of different doses of cocaine (3–30 mg/kg). Each point represents the average (+S.E.M.) rate in counts/minute determined in four to six mice for a time period of 90 minutes. Note that JHW007 attenuated the stimulation of locomotor activity produced by the highest dose of cocaine in both the DA D2 WT and KO mice. *P < 0.05 versus vehicle + vehicle; #P < 0.05 versus vehicle + cocaine.