Fig. 6.

Effects of pretreatment with BD 1008 on cocaine-induced increases in locomotor activity in Swiss-Webster mice. Ordinates: horizontal locomotor activity counts/minute. Abscissae: treatment condition, vehicle (V), or cocaine dose in mg/kg. BD 1008 (10 mg/kg) was administered immediately before administration of cocaine (5–20 mg/kg). Each point represents the average (+ S.E.M.) rate in counts/minute determined in six mice for a time period of 60 minutes. Note that BD 1008 attenuated the dose-dependent stimulation of locomotor activity produced by cocaine.