Fig. 7.

Effects of pretreatment with JHW007 on cocaine-induced increases in locomotor activity in cannabinoid CB₁R receptor WT and KO mice. Ordinates: horizontal locomotor activity counts/minute. Abscissae: treatment condition, vehicle (V), or cocaine dose in milligrams per kilograms. JHW007 (20 mg/kg) was administered 4.5 hours before administration of 20 mg/kg doses of cocaine. Each point represents the average (+S.E.M.) rate in counts/minute determined in four to six mice for a time period of 90 minutes. Note that JHW007 attenuated the stimulation of locomotor activity produced by cocaine in both the cannabinoid CB₁R receptor WT and KO mice.