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. 2014 Jan;348(1):106–115. doi: 10.1124/jpet.113.208538

Fig. 8.

Fig. 8.

Effects of pretreatment with JHW007 (A), AHN2-005 (B), AHN1-055 (C), or GBR 12909 (D) on the effects of cocaine on rearing (top panels) and sniffing (bottom panels) in mice. Ordinates: mean frequency of rearing (top) and sniffing (bottom) after drug administration. Abscissae: treatment condition, vehicle (V), or cocaine dose in milligrams per kilograms. JHW007, AHN2-005, AHN1-055, or GBR 12909 were administered 4.5, 3.5, 2.5, or 2 hours before administration of different doses of cocaine (5–60 mg/kg). Each point represents the average frequency (+S.E.M.) determined in six to eight mice over the 90-minute observation period. Note that in contrast to the other N-substituted BZT analogs and GBR 12909, JHW007 dose-dependently antagonized the increases in rearing behavior produced by cocaine. Furthermore, similar to AHN1-055 and GBR 12909, JHW007 also produced a leftward shift in the cocaine dose-effect curve; AHN2-005 had no effect on sniffing. *P < 0.05 versus vehicle + vehicle; #P < 0.05 versus vehicle + cocaine.