TABLE 4.

Statistical analyses of shifts in dose-effect curves of training drugs between the first and the last three assessments

Treatment	First vs. Last Assessments	Dose	Interaction	Post Hoc Test
d-Methamphetamine	F1,20 = 12.5; P = 0.017	F4,20 = 34.5; P < 0.001	F4,20 = 21.1; P < 0.001	0.032 mg/kg/inj, t = 6.63, P < 0.001 (decrease of 0.013 responses/s)
				0.10 mg/kg/inj, t = 5.59, P < 0.001 (decrease of 0.011 responses/s)
Heroin	F1,20 = 13.6; P = 0.014	F4,20 = 26.8; P < 0.001	F4,20 = 4.49; P = 0.009	10 µg/kg/inj, t = 3.28, P = 0.004 (increase of 0.006 responses/s)
				32 µg/kg/inj, t = 5.01, P < 0.001 (increase of 0.009 responses/s)
Ketamine	F1,20 = 8.99; P = 0.030	F4,20 = 11.8; P < 0.001	F4,20 = 5.66; P = 0.003	0.32 mg/kg/inj, t = 5.37, P < 0.001 (increase of 0.075 responses/s)