Skip to main content
. 2014 Jan;85(1):11–17. doi: 10.1124/mol.113.089979

Fig. 3.

Fig. 3.

Responses of pentamers containing α5. The left column shows responses of receptors formed from β2-α4-α5-α4-β2 pentamers, and the right column from β2-α4-α5-α4-α4. (A) Responses to agonists; note that in the left column 5I A85380 produces a larger response than 1 mM ACh, and that 10 μM ACh is clearly a more than half-maximal concentration. In contrast, in the right column 5I A85380 produces a smaller response than 1 mM ACh, and 10 μM ACh is clearly a less than half-maximal concentration. (B and C) Responses to 0.3 μM ACh; then the application is switched to 0.3 μM ACh plus 15 μM physostigmine (PHY; B) or 10 μM 17β-estradiol (βEST; C). Both drugs inhibit responses of β2-α4-α5-α4-β2 pentamers but potentiate responses of β2-α4-α5-α4-α4. Each frame in A shows responses from one oocyte, while each frame in B and C shows responses from separate oocytes.