Fig. 2.

Some, but not all, antiallergenics are GPR35 agonists. The ability of a range of compounds that have effectiveness as antiallergenics and mass cell stabilizers, including lodoxamide (●), bufrolin (□), amlexanox (▴), doxantrazole (◇), pemirolast (▿), and cromolyn disodium (○), to promote interactions between human GPR35a (A) or human GPR35b (B) and β-arrestin-2 was compared with the prototypic GPR35 agonist zaprinast (♦) in BRET-based assays. As noted in Results, the absolute signals obtained using GPR35b were substantially lower than when using GPR35a.