Fig. 3.

In vivo clearance of LVS in LCN and WT mice. Plasma levels of LVA were determined after a single dose of LVS (5–50 mg/kg, as indicated) via oral gavage. Adult female mice were studied. Plasma samples were obtained at various times after dosing. The results shown are typical of two separate experiments. Values represent means ± S.D. (n = 5 to 6). **P < 0.01; compared with WT mice (Student’s t test).