TABLE 1.

Pharmacokinetic parameters for plasma LVA in LCN and WT mice

Data from Fig. 3 were used for the determination of pharmacokinetic parameters, as described in Materials and Methods. Values represent means ± S.D. (n = 5 to 6).

Strain	Dose	Tmax	Cmax	t1/2	AUC0–4h	CL/F
	mg/kg	min	μg/ml	min	min ⋅µg/ml	ml/min
WT	50	27.4 ± 7.8	0.67 ± 0.11	49.6 ± 10.0	56.5 ± 8.9	18.1 ± 3.0
LCN		33.8 ± 10.6	1.30 ± 0.19*	68.2 ± 14.7**	154.5 ± 30.6*	6.7 ± 1.4*
WT	5	15.0 ± 0	0.067 ± 0.008	27.4 ± 12.2	4.1 ± 1.1	29.1 ± 9.2
LCN		20.0 ± 8.7	0.033 ± 0.004**	26.7 ± 12.8	2.1 ± 0.4**	49.4 ± 10.2

AUC, area under the curve.

^*P < 0.01; **P < 0.05; compared with the corresponding WT group (Student’s t test).