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Affinity and potency values for morphinans using GloSensor and Tango assays
| Morphinans | G Protein EC50 | G Protein Emax | Arrestin EC50 | Arrestin Emax | Bias Factor |
|---|---|---|---|---|---|
| nM | nM | ||||
| Salvinorin A | 5.18 (−8.29 ± 0.10) | 99.7 | 5.75 (−8.24 ± 0.06) | 97.2 | 1 |
| β-NNTA | 0.305 (−9.52 ± 0.12) | 97.0 | 0.268 (−9.57 ± 0.12) | 84.5 | 1 |
| 6′ GNTI | 4.74 (−8.32 ± 0.09) | 96.5 | 7.38 (−8.13 ± 0.12) | 34.7 | 6 G protein |
| 5′ GNTI | Antagonist | — | Antagonist | — |
