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. 2013 Sep 9;90(2):443–455. doi: 10.1111/mmi.12376

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2013 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Virulence of parasites in mice. Groups of 5 mice were infected intraperitoneally with WT or DKO parasites after various culturing conditions.A. Virulence of T. brucei cultured in TBM^FCS. Inoculum: 10⁴ WT parasites (open circles) or 10⁴ DKO parasites (closed circles)B. Virulence of T. brucei after prolonged culture in HMI9T. Inoculum: WT parasites 10⁴ (open circles) or 10⁶ (open squares); DKO parasites 10⁴ (closed circles) or 10⁶ (closed squares).C. Virulence of DKO parasites after short-term culture in TBM^FCS plus thymidine versus HMI9T. Inoculum: 10⁴ WT parasites cultured in HMI9T (open squares); 10⁴ DKO parasites cultured in either HMI9T (open circles) or TBM^FCS plus thymidine (closed circles). Another group of five mice were infected with 10⁴ DKO parasites isolated from an infected mouse in panel B (closed squares). Infections in all three studies were monitored over a period of 30 days and data are presented in the form of a Kaplan–Meier survival plot.