Figure 2. Schematic representation of the HCV replicons.

The coding regions in the HCV polyproteins are indicated by the open boxes. The bold lines indicate the HCV 5′-untranslated region (UTR), which is the target of sh277 and sh331 (arrows), and the 3′-UTR. Gray bars, EMCV internal ribosome entry site; dC, 5′-region of Core gene; neo, neomycin-resistance gene; Luc-neo, firefly luciferase gene fused with neo gene.