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. 2013 Dec 20;3:3450. doi: 10.1038/srep03450

Figure 7. Effects of ALK inhibitor TAE-684 on NBL cells and xenograft tumors.

Figure 7

(a) TAE-684 reduced the proliferation of NBL cells. MYCN-non-amplified (SK-N-AS and RISA) or amplified (GOTO, NLF and SK-N-DZ) NBL cells were cultured with varying concentrations of TAE-684 for 72 h and cell proliferation was measured. The values are mean ± SD of triplicate experiments. (b) TAE-684 suppressed cell migration and invasion of NBL cells with MYCN amplification. NBL cells with MYCN amplification (SK-N-DZ and NLF) or without amplification (SK-N-AS) were treated with 50 nM or 200 nM of TAE-684 or DMSO as control, and cell migration (upper panel) or invasion (lower panel) assays were performed. The values are mean ± SD of triplicate experiments. (c) TAE-684 suppressed tumor growth in mice. SK-N-DZ (left panel) and NLF (right panel) cells were subcutaneously injected into mice. When palpable tumors appeared, mice were orally treated with TAE-684 or carrier solution (vehicle), and tumor sizes were measured. Tumor sizes are displayed as mean ± SD at the indicated time interval of TAE-684 treatment (upper panel). Pictures of subcutaneous tumors for each group are shown (lower panel). n = 6 for each group of SK-N-DZ cells and n = 5 for each group of NLF cells.