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. Author manuscript; available in PMC: 2014 Sep 13.
Published in final edited form as: Circ Res. 2013 Sep 13;113(7):10.1161/CIRCRESAHA.113.300215. doi: 10.1161/CIRCRESAHA.113.300215

Figure 3.

Figure 3

Protein engineering methods to enable drug delivery. Numerous techniques within the realm of protein engineering could be employed to enhance delivery of small molecules, proteins and nucleic acids to the heart. Examples shown above include the targeting of a nanocarrier to a cell type of interest (e.g. cardiomyocytes, endothelial cells, etc.) by a peptide molecule derived via molecular display and the enhancement of cellular internalization of a therapeutic entity via fusion with a protein transduction domain (PTD).