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. 1986 Nov;83(21):8226–8230. doi: 10.1073/pnas.83.21.8226

Modulation of epidermal growth factor receptors by human alpha interferon.

K C Zoon, Y Karasaki, D L zur Nedden, R Q Hu, H Arnheiter
PMCID: PMC386900  PMID: 3095830

Abstract

Treatment of Madin-Darby bovine kidney (MDBK) cells with human interferon (IFN)-alpha 2 at 37 degrees C results in a dose-dependent inhibition of cell growth and a reduction of the subsequent binding of 125I-labeled epidermal growth factor (EGF) at 4 degrees C. Human IFN-beta and -gamma, which exhibit little antiviral and antiproliferative activities on MDBK cells, have little effect on cell growth or the binding of 125I-labeled EGF to these cells. The binding of EGF is decreased after exposure to IFN-alpha for greater than 8 hr. Scatchard analyses of the EGF binding data indicate that a 20-hr exposure period results in a decrease in the apparent number of cell-surface EGF receptors and a reduction in the affinity of EGF for its receptor. The rate of internalization of EGF by MDBK cells does not appear to be affected by IFN treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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