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. 2013 Aug 15;8(1):88–102. doi: 10.1038/ismej.2013.120

Figure 3.

Figure 3

Identified enzymes involved in the methanogenesis and Acetyl-CoA pathways mapped over generic pathways. : proteins identified during the study. Red: hydrogenotrophic methanogenesis. Blue: acetoclastic methanogenesis. Green: methylotrophic methanogenesis. Purple: Eastern branch of the acetyl-CoA pathway. Orange: Western branch of the acetyl-CoA pathway. : membrane proteins. (Cofactors): key enzymes for the biosynthesis of cofactor. (1) Formylmethanofuran dehydrogenase, FwdA-F or FmdA-F; (2) Formylmethanofuran—tetrahydromethanopterin N-formyltransferase, Ftr; (3) Methenyltetrahydromethanopterin cyclohydrolase, Mch; (4) Methylenetetrahydromethanopterin dehydrogenase, Hmd/mtd; (5) Coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase, Mer; (6) Tetrahydromethanopterin S-methyltransferase, Mtr; (7) Methyl-coenzyme M reductase, MrtABG or McrABG; (8) Membrane hydrogenase, Ech, Eha or Ehb, Rnf, Fpo; (9) Coenzyme F420 hydrogenase, Frh, Fru, Frc; (10) F420 non-reducing hydrogenase/heterodisulfide reductase complex, MvhADG-HdrABC or VhoACG-HdrDE; (11) ATPase, AhaA-K; (12) Acetate kinase, Ack; (13) Phosphotransacetylase, Pta; (14) Carbon monoxide dehydrogenase/acetyl-coA synthase complex, CODH/ACS; (15) Carbon monoxide dehydrogenase/acetyl-coA synthase/decarbonlyase (CODH/ACDS) complex; (16) Methylcobamide:CoM metyltransferase, MtaABC, Mtb, Mtm, Mtq, Mts or Mtt; (17) Formate dehydrogenase, Fdh; (18) Na+/H+ antiporter; (19) Coenzyme F390; (20) Formyltetrahydrofolate (CHO-THF) synthetase, Fhs or FTHFS; (21) Biofunctional protein—Methenyltetrahydrofolate (CH-THF) cyclohydrolase and methylenetetrahydrofolate (CH2-THF) dehydrogenase complex, FolD; (22) Methylenetetrahydrofolate (CH2-THF) reductase, MetF or MTHFR; (23) THF:Fe-S-Co Methyltransferase, MeTr. See also Supplementary Table S7.