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. Author manuscript; available in PMC: 2013 Dec 20.
Published in final edited form as: Dev Biol. 2005 Oct 11;288(2):10.1016/j.ydbio.2005.09.024. doi: 10.1016/j.ydbio.2005.09.024

Fig. 12.

Fig. 12

Increased nephrogenic mesenchyme cell death in the Odd1−/− mutant embryos. (A, B) Transverse sections at hindlimb bud levels of E10.5 wildtype (A) and Odd1−/− mutant (B) embryos were stained for apoptotic cells using TUNEL assay. Arrows point to the nephric ducts and arrowheads point to metanephric mesenchyme. (C, D) Transverse sections of lower trunk regions of E9.5 wildtype (C) and Odd1−/− mutant (D) embryos were stained for Caspase-3 expression (red). The sections were counterstained with DAPI (blue) to show cell nuclei. Arrowheads point to the nephrogenic mesenchyme, which contains significant numbers of Caspase-3 positive cells in the Odd1−/− mutant embryo (D). da, dorsal aorta; hg, hindgut; so, somite; +/+, wildtype; −/− homozygous mutant.