Table 6.

TTP and OS by median dichotomized enzyme variables

End Point + Enzyme Variable (dichotomized level)	No. Pts	No. Events	End Point	Point Estimate	90% CI
TTP
Tumor tissue TS:
Low (21.71 or less)	11	10	Median 6-Mo rate	5.1 Mos 45%	3.0–8.1 21–70
High (greater than 21.71)	11	11	Median 6-Mo rate	6.6 Mos 63%	5.9–7.1 38–88
Tumor tissue TP:
Low (3.8 or less)	11	10	Median 6-Mo rate	6.7 Mos 63%	6.0–7.7 39–88
High (greater than 3.8)	11	11	Median 6-Mo rate	5.1 Mos 45%	3.0–5.8 20–69
Tumor tissue DPD:
Low (105.82 or less)	11	10	Median 6-Mo rate	5.1 Mos 45%	3.0–6.2 21–70
High (greater than 105.82)	11	11	Median 6-Mo rate	6.6 Mos 63%	5.9–7.5 38–88
Tumor tissue TP/DPD:
Low (0.58 or less)	11	10	Median 6-Mo rate	7.1 Mos 72%	6.2–9.9 49–96
High (greater than 0.58)	11	11	Median 6-Mo rate	4.0 Mos 36%	3.7–6.4 12–59
Blood (serum) DPD:
Low (0.79 or less)	11	11	Median 6-Mo rate	6.6 Mos 63%	5.9–11.2 38–88
High (greater than 0.79)	12	12	Median6 Mo rate	6.0 Mos 50%	3.3–7.1 26–74
OS
Tumor tissue TS:
Low (21.71 or less)	11	8	Median 12-Mo rate	16.7 Mos 76%	11.8–22.2 54–98
High (greater than 21.71)	11	9	Median 12-Mo rate	15.8 Mos 83%	8.0–21.2 64–100
Tumor tissue TP:
Low (3.8 or less)	11	7	Median 12-Mo rate	18.0 Mos 89%	14.0–24.9 68–100
High (greater than 3.8)	11	10	Median 12-Mo rate	13.8 Mos 82%	12.1–26.1 63–100
Tumor tissue DPD:
Low (105.82 or less)	11	9	Median 12-Mo rate	17.0 Mos 80%	12.9–23.8 58–100
High (greater than 105.82)	11	8	Median 12-Mo rate	15.4 Mos 91%	7.5–25.3 77–100
Tumor tissue TP/DPD:
Low (0.58 or less)	11	7	Median 12-Mo rate	21.9 Mos 88%	16.4–23.2 68–100
High (greater than 0.58)	11	10	Median 12-Mo rate	14.1 Mos 82%	11.9–14.8 63–100
Blood (serum) DPD:
Low (0.79 or less)	11	5	Median 12-Mo rate	23.7 Mos 83%	19.7–* 64–100
High (greater than 0.79)	12	11	Median 12-Mo rate	15.1 Mos 78%	14.2–25.8 58–99

^*Not available due to censoring pattern.