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Potential/hypothetical pathways modified by EphrinA1-EphA signaling. EphrinA1 potentially mediates cardioprotection during myocardial infarction by increasing phosphorylated-Akt to decrease apoptosis through upregulating bcl-2 and decreases the inflammatory response through the downregulation of NF-κB. The possible promotion of autophagy is mediated through the downregulation of mTOR and subsequent increase in AMPK.
