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. 2013 Nov 7;9:2387–2394. doi: 10.3762/bjoc.9.275

Table 2.

Synthesis of 3-trifluoromethyl-2-isoxazolines and isoxazoles by reaction between aldoxime 2 and olefins or alkynes in the presence of DIB.

graphic file with name Beilstein_J_Org_Chem-09-2387-i002.jpg

entry substrate product isolated yield (%)

1 Inline graphic
5a
Inline graphic
1a
76
2 Inline graphic
5b
Inline graphic
1b
90
3 Inline graphic
5c
Inline graphic
1c
91
4 Inline graphic
5d
Inline graphic
1d
64
5 Inline graphic
5e
Inline graphic
1e
51
6 Inline graphic
5f
Inline graphic
1f
56
7 Inline graphic
5g
Inline graphic
1g
82
8 Inline graphic
5h
Inline graphic
1h
74
9 Inline graphic
5i
Inline graphic
1i
24
10 Inline graphic
5j
Inline graphic
1j
20
11 Inline graphic
5k
Inline graphic
1k
traces
12 Inline graphic
5l
Inline graphic
1l
53
13 Inline graphic
5m
Inline graphic
1m
50
14 Inline graphic
5n
Inline graphic
1n
traces