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Optimization of Cu–H-catalysed reduction of 16.
| entry | Cu(OAc)2·H2O (mol %) | BDP (mol %) | PMHS (equiv) | solvent | yield of 14 |
| 1 | 5 | 1 | 2 | toluene/t-BuOH (5:1) | 72% |
| 2 | 5 | 1 | 2 | toluene/t-BuOH (2:1) | 78% |
| 3 | 1 | 0.5 | 1.2 | toluene/t-BuOH (2:1) | 67% |
| 4a | 5 | 1 | 2 | toluene | 87% |
aTBAF (2 equiv) added after complete consumption of starting material.
